Some optical detection methods use light sources as delivery or collection media to obtain signals. Honestly, each detection method has its advantages and drawbacks. So far, various detection technologies such as electrochemistry (EC), electrochemiluminescence (ECL), colorimetry, fluorescence (FL), surface-enhanced Raman scattering (SERS) and chemiluminescence (CL) have been assembled on μPads. Īs fast response rate and high sensitivity are the main demands for POCT, the detection system is vital for signal acquisition. Also, μPads provide a good platform for sample pretreatment, reagent transportation, mixing, separation and detection and other analytical functions. High-throughput determination of the content of multiple components in samples can be realized on μPads. The μPads prepared by these advanced fabrication methods greatly expand the potential applications because paper can be used as the fine substrate for POCT devices. Then the paper permeability and surface reaction activity are changed to create reaction channels for the migration, storage and reaction of reagents. So hydrophilic and hydrophobic regions can be easily constructed on the paper surface. We all know that hydroxyl groups on the paper are simple to be modified. ΜPads have been prepared by a variety of methods, such as photoetching, inkjet printing, wax printing, laser processing, plasma processing, cutting, one-step plotting technology, flexographic printing, and stereoscopic printing. Then the development of μPads has shown exponential growth in recent years. μPads have the advantage of low production cost, simple method, easy processing, good biocompatibility, and small reagent consumption. The sample and reaction solution are driven by the capillary force of paper. It is an analytical platform that integrates the function of injection, reaction, separation and detection into paper by building hydrophilic and hydrophobic channels. It miniaturizes the principal use of chemistry, biology and other laboratories to a small space of paper. μPads are also known as lab-on-a-chip (LOC), which are proposed by Whitesides’ group in 2007. Nowadays, the technological challenge in the field of microfluidic paper-based analytical devices (μPads) is the main support for POCT systems. Compared to central laboratory testing, POCT system has advantages of immediate turn-around time, easy-to-use format, high sensitivity and accuracy. By using low-volume of samples, POCT can be realized in hospitals, clinics, doctor's offices or homes.
IOS MAIL 10.2 ATTACHMENT TAMER PORTABLE
Point-of-care testing (POCT) is a low-cost, user-friendly, and portable technology that uses fast and convenient analytical instruments to obtain test results immediately at the sampling point.